A hard-working small business owner (Vince Vaughn) and his two associates (Tom Wilkinson, Dave Franco) travel to Europe to close the most important deal of their lives. But what began as a routine business trip goes off the rails in every imaginable - and unimaginable - way, including unplanned stops at a massive sex fetish event and a global economic summit.

The small harbor of Tickle Cove is in dire need of a doctor so that the town can land a contract to secure a factory which will save the town from financial ruin. Village resident Murray French (Gleeson) leads the search, and when he finds Dr. Paul Lewis (Kitsch) he employs - along with the whole town - tactics to seduce the doctor to stay permanently.

At 42, David lives the life of an irresponsible adolescent. He coasts through life with minimal effort and maintains a complicated relationship with Valerie, a young policewoman. Just as she tells him she's pregnant, David's past resurfaces. Twenty years earlier, he began providing sperm to a fertility clinic in exchange for money. He discovers he's the father of 533 children, 142 of whom have filed a class action lawsuit to determine the identity of their biological father, known only by the pseudonym Starbuck.

Eve White is a quiet, mousy, unassuming wife and mother who keeps suffering from headaches and occasional black outs. Eventually she is sent to see psychiatrist Dr. Luther, and, while under hypnosis, a whole new personality emerges: the racy, wild, fun-loving Eve Black. Under continued therapy, yet a third personality appears, the relatively stable Jane. This film, based on the true-life case of a multiple personality, chronicles Dr. Luther's attempts to reconcile the three faces of Eve. multiple personalities.